Sural Nerve Sorbitol in Patients With Diabetic Sensorimotor Polyneuropathy
نویسندگان
چکیده
منابع مشابه
Sural nerve sorbitol in patients with diabetic sensorimotor polyneuropathy.
OBJECTIVE Nerve sorbitol levels have been measured in sural nerve biopsy samples from patients with diabetic sensorimotor polyneuropathy in several studies using different methods and measurement units. In this study, we compared the results of sorbitol assays to determine the required sensitivity of analytical methods for nerve sorbitol measurements. RESEARCH DESIGN AND METHODS We performed ...
متن کاملAldose reductase inhibition by AS-3201 in sural nerve from patients with diabetic sensorimotor polyneuropathy.
OBJECTIVE The primary purpose of this investigation was to determine whether AS-3201, a new aldose reductase inhibitor, penetrates the sural nerve and inhibits sorbitol and fructose accumulation in patients with diabetic sensorimotor polyneuropathy (DSP). An additional aim was to determine whether any changes in nerve function would manifest with AS-3201 therapy. RESEARCH DESIGN AND METHODS P...
متن کاملConduction Slowing in Diabetic Sensorimotor Polyneuropathy
OBJECTIVE Mild demyelination may contribute more to the pathophysiology of nerve fiber injury in diabetic sensorimotor polyneuropathy (DSP) than previously thought. We investigated the clinical and electrodiagnostic classifications of nerve injury in diabetic patients to detect evidence of conduction slowing in DSP. RESEARCH DESIGN AND METHODS Type 1 diabetic subjects (n = 62) and type 2 diab...
متن کاملCubital Tunnel Syndrome Caused by Ulnar Nerve Schwannoma in a Patient with Diabetic Sensorimotor Polyneuropathy.
PURPOSE An uncommon ulnar nerve schwannoma should not be neglected in a diabetic patient with cubital tunnel syndrome, the second most common cause of entrapment neuropathy. CASE REPORT A 61-year-old woman with a past history of type 2 diabetes mellitus complicated with sensorimotor polyneuropathy presented with progressive numbness and weakness of the left ring and little fingers for one yea...
متن کاملTwo-segment sural nerve conduction measurements in polyneuropathy.
Sensory conduction velocity of the sural nerve was measured in 50 normal subjects and 100 consecutive patients with suspected or established diagnosis of peripheral neuropathy. The sensory action potential was recorded by the orthodromic technique for the distal and the proximal segments. In the patient group, sensory conduction of the proximal segment appeared to be more consistent and easier ...
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ژورنال
عنوان ژورنال: Diabetes Care
سال: 2004
ISSN: 0149-5992,1935-5548
DOI: 10.2337/diacare.27.5.1160